TABLE 1.

Genes from PC-3 cells that are significantly up- or down-regulated after treatment with quercetin, as analyzed by the gene array methodology^a

Gene array	Genes whose level is modulated less than or more than 50%	% Increase or decrease in gene expression
Cell cycleb	CCND1	65
	CCND2	CS
	CCND3	CS
	CCNF1	CS
	CCNE2	CS
	CDK2	CS
	CDK4	CS
	E2F2	CS
	E2F3	CS
	CDK8	50
	CDC 7L1	CS
	PCNA	CS
	CCNF	CS
	CDC2	CS
	CDC16	CS
	CUL4B	NI
Tumor suppressorc	CREB-binding protein	71
	Phospatase and tensin homolog	72
	MutS homolog 2	71
	Cyclin-dependent kinase inhibitor 1A (p21, CiP1)	57
	CREB-binding protein (p300)	72
	Von Hippel-Lindau syndrome	67
	Breast Cancer 1, early onset	82
	Tuberous sclerosis 1	52
	Transforming growth factor β2 receptor	92
	Adenomatosis polyposis coli	NI
	Transforming growth factor, beta receptor 11	NI
	Tumor suppressor protein p53	NI
	Retinoblastoma 1	NI
	Cyclin-dependent kinase inhibitor 1C	NI
	Tuberous sclerosis 2	NI
Oncogeneb	v-akt murine thymoma viral oncogene homolog 1	61
	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	89
	Breakpoint cluster region	CS
	v-myb avian myeloblastosis viral oncogene homolog	CS

^aGene expression was normalized to the expression of the β-actin gene, provided as a housekeeping gene in the array kit. The results are expressed as the percent increase or decrease of gene expression in PC-3 cells treated with quercetin compared to that in control PC-3 cells, after normalization. See Fig. 2. CS, complete suppression; NI, newly induced.

^bFor this array, genes are listed in order of decreasing expression.

^cFor this array, genes are listed in order of increasing expression.