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. 2011 Aug 25;54(3):999–1008. doi: 10.1002/hep.24501

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Copyright © 2011 American Association for the Study of Liver Diseases

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Fig. 7 — Extracellular histones enhances the nucleic acid–mediated damage after hepatic I/R. (A) IL-6 mRNA expression was obtained in NPCs cocultured overnight with media from necrotic hepatocytes. NPCs were treated with vehicle PBS, Dnase I, or anti-histone H4 antibody. Results are expressed as the relative increase of mRNA expression compared with PBS treatment. Data represent the mean ± SE and are representative of three experiments with similar results. *P < 0.05. (B) IL-6 mRNA expression was observed in NPCs that were treated with vehicle PBS, CpG, exogenous histones, or both. Results are expressed as relative increase of mRNA expression compared with PBS treatment. Data represent the mean ± SE and are representative of three experiments with similar results. *P < 0.05.