Fig. 1.

Similar levels of ApoB and Fatp5 mRNAs were observed for all groups containing siRNAs targeting these genes, either alone or in combination. Mice (n = 8/group) were treated with siRNAs targeting ApoB and Fatp5 alone or in combination (ApoB, Fatp5, Fatp5/ApoB) at days 0 and 14. Gene expression was analyzed using qRT-PCR (TaqMan) on day 21 (a, b) post the initial dose. PBS and a control siRNA (cntrl siRNA) served as negative controls. Data represented as the log2 fold change (ddCt) relative to the cntrl siRNA treatment of individual animals (circles) and the group means (bars) are shown