Figure 2 .

Heart-specific knockdown of RpS15Aa severely impairs cardiac function in adult Drosophila. (A) Representative images of bristles in w¹¹¹⁸ control, Df(1)Exel6245/FM7c, and Df(1)f08066-f07791/FM7c. Both deletions have characteristically Minute bristles that are shorter and thinner than wild-type bristles. (B) Heart-specific tinC-Gal4 driving expression of RNAi against RpS15Aa causes a severe cardiac phenotype and severely reduced eclosion. Representative OCT M-mode images of the few eclosed adults (n = 4) showed severely impaired heart function compared to control of UAS-RNAi alone without driver (n = 12). *P < 0.001 vs. no driver control, unpaired t-test.