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. 2011 Nov;189(3):861–870. doi: 10.1534/genetics.111.131482

Table 1. Cardiomyopathy correlates with the Minute phenotype in Drosophila melanogaster.

Gene (synonym) Bristle phenotypea Heart phenotype Allele Genes
affected EDDb
(µm) ESDb (µm) FSb
(%) n =
Control Normal Normal w1118 81 ± 4 2 ± 1 98 ± 1 16
Chromosome X
RpL36 Minute Abnormal Df(1)y74k24.1 >30 123 ± 6 29 ± 9 78 ± 6 8
RpL7A Minute Abnormal Df(1)dx81 >100 96 ± 5 23 ± 5 78 ± 5 14
RpS15Aa Minute Abnormal Df(1)f08066-f07791 3 131 ± 12 32 ± 10 78 ± 5 9
eIF-2α Minute Abnormal Df(1)ED7364 45 107 ± 4 22 ± 4 79 ± 4 4
RpS5a Minute Abnormal RpS5a1 1 104 ± 6 24 ± 5 78 ± 4 14
mRpS14 Normal Normal Df(1)e00904-d02459 9 70 ± 3 5 ± 1 93 ± 4 22
Chromosome 2
RpLP1 Minute Abnormal RpLP1beo 1 84 ± 4 17 ± 4 81 ± 4 16
RpS21 (oho23B) Minute Abnormal Df(2L)JS31 ∼70 91 ± 10 29 ± 10 71 ± 11 4
RpL40 Minute Abnormal Df(2L)BSC217 20 82 ± 5 28 ± 4 67 ± 4 11
RpS13 Minute Abnormal RpS131 1 109 ± 5 35 ± 6 69 ± 5 12
RpL27A Minute Abnormal RpL27A1 1 90 ± 5 28 ± 5 69 ± 4 11
RpS26 Minute Abnormal Df(2L)Exel8038 26 89 ± 4 22 ± 6 75 ± 7 7
RpL5 Minute Abnormal RpL52d2 1 98 ± 7 22 ± 5 80 ± 4 7
mRpL10 Normal Normal Df(2L)Exel7002 18 82 ± 7 7 ± 3 93 ± 3 14
mRpL48 Normal Normal Df(2L)Exel6005 16 76 ± 6 5 ± 2 95 ± 2 16
mRpS2 Normal Normal mRpS2EY10086 1 63 ± 3 1 ± 1 99 ± 1 14
mRpL24 Normal Normal Df(2L)Exel7021 22 92 ± 7 12 ± 5 87 ± 5 10
mRpL28 Normal Normal Df(2L)Exel7021 22 92 ± 7 12 ± 5 87 ± 5 10
RpS28-like Normal Normal Df(2L)ED678 65 94 ± 3 1 ± 1 99 ± 0 8
RpS2 (sop) Normal Normal Df(2L)ED695 40 76 ± 4 1 ± 0 99 ± 0 11
mRpL52 Normal Normal Df(2R)Exel7092 20 54 ± 5 11 ± 5 85 ± 6 12
RpS15Ab Normal Normal Df(2R)ED2098 56 85 ± 4 4 ± 1 96 ± 2 12
Chromosome 3
RpS17 Minute Abnormal RpS176 1 92 ± 6 15 ± 4 83 ± 4 11
RpS29 Minute Abnormal Df(3R)ED5454 68 97 ± 2 19 ± 5 81 ± 5 9
RpS25 Minute Abnormal Df(3R)ED5518 80 86 ± 4 23 ± 5 73 ± 6 9
RpS3 Minute Abnormal RpS3Plac92 1 84 ± 3 28 ± 4 64 ± 6 7
mRpL17 Normal Normal Df(3L)Exel6084 43 66 ± 6 18 ± 6 86 ± 7 7
mRpL23 Normal Normal Df(3L)ED4287 85 76 ± 9 9 ± 3 86 ± 5 7
mRpS35 Normal Normal Df(3L)Exel6091 13 69 ± 6 7 ± 2 93 ± 3 12
mRpS6 Normal Normal Df(3L)ED4342 48 83 ± 5 5 ± 3 94 ± 3 14
mRpL12 Normal Normal mRpL1210534 1 81 ± 3 6 ± 3 94 ± 3 11
mRpL2 Normal Normal Df(3L)ED4470 121 85 ± 5 7 ± 3 93 ± 3 11
RpL10Ab Normal Normal Df(3L)ED4470 121 85 ± 5 7 ± 3 93 ± 3 11
mRpL20 Normal Normal Df(3L)ED4486 64 78 ± 6 3 ± 3 97 ± 3 15
RpS12 Normal Normal Df(3L)ED4486 64 78 ± 6 3 ± 3 97 ± 3 15
mRpL39 Normal Normal Df(3L)ED217 98 84 ± 4 4 ± 2 96 ± 3 16
mRpS34 Normal Normal Df(3L)ED4606 148 113 ± 5 1 ± 1 99 ± 1 14
mRpS26 Normal Normal Df(3L)ED4710 81 79 ± 4 2 ± 2 96 ± 3 14
mRpS9 Normal Normal Df(3R)ED7665 131 75 ± 5 7 ± 3 91 ± 3 12
mRpL1 Normal Normal Df(3R)ED5230 103 73 ± 3 4 ± 2 96 ± 3 21
mRpL19 Normal Normal Df(3R)ED5330 71 75 ± 6 3 ± 3 96 ± 4 5
mRpS21 Normal Normal Df(3R)ED5612 104 71 ± 5 1 ± 1 90 ± 1 14
mRpS33 Normal Abnormal mRpS33f01766 1 97 ± 6 24 ± 6 78 ± 5 16
mRpS11 Normal Normal Df(3R)ED5780 100 87 ± 3 4 ± 2 96 ± 2 13
mRpL55 Normal Normal Df(3R)ED5938 73 69 ± 5 7 ± 3 91 ± 4 12
Chromosome 4
RpS3A Minute Abnormal RpS3A57g 1 117 ± 5 42 ± 7 65 ± 5 10
a

Bristle phenotypes were confirmed as published (Duffy et al. 1996; Marygold et al. 2007) or visually confirmed in the case of custom deletions or obtained P-element stocks.

b

Cardiac chamber measurements: end-diastolic dimension (EDD), end-systolic dimension (ESD), and fractional shortening (FS: (EDD − ESD)/EDD × 100). Values are expressed as the mean ±SEM. Abnormal heart function is noted by a significant increase in ESD and a significant decrease in fractional shortening compared to w1118 control. One-way Anova with Dunnett Multiple Comparisons test.