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Acetylcholine potentiates AVM axon guidance through UNC-6– and SLT-1–induced signaling. Diagram showing the sites of action of the molecules described. Acetylcholine secreted by ventral nerve cord cholinergic neurons is sufficient to enhance the AVM response to UNC-6 and SLT-1 guidance cues through its interaction with AVM acetylcholine receptors. RPM-1 and CLEC-38 act within AVM to negatively regulate the guidance signaling and have the opposite effect of acetylcholine.
