Table 2.

Effect of rs1466535 Genotype on LRP1 Expression

Tissue	Number	CC versus TT Fold-Change (95% CI)
Aortic adventitia	133	1.19 (1.04–1.36)
Aortic intima media	138	1.17 (0.96–1.42)
Mammary artery intima media	89	1.24 (0.99–1.56)
Liver	212	0.99 (0.91–1.07)

Tissue samples were obtained from 316 patients undergoing aortic valve surgery; 572 unique tissue samples were analyzed. Extracted RNA was hybridized to Affymetrix ST 1.0 Exon arrays and obtained scans were RMA normalized and log2 transformed. DNA was extracted from circulating blood cells and hybridized to Illumina 610w-Quad BeadArrays. rs1466535 genotype was directly measured. Estimates of genotype effect on expression of genes were calculated with an additive linear model. The fold-change is calculated as the difference between the mean expression levels in the CC homozygotes compared to the TT homozygotes. Values greater than one correspond to higher expression in CC homozygous individuals. The results for aortic adventitia are shown in Figure S5.