Table 5.

This table is an additive stepwise regression model, which begins by including the covariates from Tables 3 and 4 (age, gender, socio-economic status (SES) score and weight-for-age z score (WAZ: Epi Info CDC 2000). These are followed by the cerebral malaria with positive retinopathy (CM-R) clinical measures of HIV status (positive, negative), a reported history of seizures prior to CM illness (History seizures: yes, no), occurrence of observed seizures at admission or during hospitalization (Seizures in hospital: yes, no), confirmed epilepsy 1 year after illness (Epilepsy after illness: yes, no), duration of coma following admission (h), blood haematocrit level at admission (%), serum platelet counts at admission (µl) and serum lactate level at admission (absolute). The predicted outcome measures are the Malawi Developmental Assessment Tool (MDAT) domain scores (Gross Motor, Fine Motor, Language, Social Skills), MDAT total score and Child Behaviour Checklist (CBCL) Internalizing and Externalizing Symptoms total. The stepwise regression stops when all remaining variables have P-values >0.15. Empty cells indicate that the enter P-value was >0.15. Only the CM-R group is included in this table. Total percentage of explained variance for that outcome measure (R²) is in the bottom row of the table

Clinical factor	N	MDAT gross motor	MDAT fine motor	MDAT language	MDAT social skills	MDAT total score	CBCL internalizing symptoms	CBCL externalizing symptoms
Age (years)	83	0.000	0.000	0.000	0.000	0.000	0.598	0.711
Gender	83	0.624	0.495	0.848	0.881	0.873	0.782	0.490
WAZ	83	0.004	0.049	0.145	0.002	0.015	0.050	0.575
SES	83	0.600	0.173	0.901	0.456	0.256	0.251	0.685
HIV status	71
History of seizures	83
Seizures in hospital	83						0.037
Epilepsy after illness	79
Coma duration	79	0.001			0.085
haematocrit	76
Blood platelets	68		0.007	0.066		0.010	0.127	0.088
Lactate	76		0.002	0.001		0.002		0.114
R2		67.6%	64.6%	54.5%	47.2%	66.8%	21.5%	17.0%