Table 2.
Isometric contractile properties of control and dexamethasone (DEX)-treated wild type (WT) and MuRF1 null (KO) mice
| WT Con (n = 7) | WT DEX (n = 8) | KO Con (n = 5) | KO DEX (n = 6) | |
|---|---|---|---|---|
| Twitch time to peak tension (ms) | 17.3 ± 3.1 | 21.2 ± 4.5 | 17.1 ± 5.2 | 20.1 ± 2.2 |
| Twitch half-relaxation time (ms) | 13.9 ± 4.7 | 14.6 ± 4.1 | 15.0 ± 2.2 | 15.4 ± 2.7 |
| Twitch peak tension (mN) | 579.6 ± 88.9 | 604.5 ± 135.2 | 539.2 ± 81.9 | 580.9 ± 28.9 |
| Maximum isometric tension (mN) | 2086.7 ± 448.9 | 2109.3 ± 529.1 | 1802.8 ± 400.9 | 2262.1 ± 374.1 |
| Specific tension (N cm−2) | 25.3 ± 4.8 | 30.6 ± 7.7 | 22.8 ± 3.9 | 28.2 ± 8.1 |
| Twitch/tetanic ratio | 0.28 ± 0.03 | 0.29 ± 0.07 | 0.25 ± 0.04 | 0.26 ± 0.03 |
The isometric contractile properties of the gastrocnemius muscle were measured in female WT and MuRF1 KO mice following 14 days of DEX treatment. The twitch to tetanic ratio was calculated as the peak twitch tension divided by the maximum isometric force. The data are expressed as mean ± SD for a sample size equal to n.