FIG. 7.

SIV-induced upregulation of Plk1 correlates with viral load in RM. CD4⁺ T cells from SIV-seronegative SM (SM−), SIV-seropositive SM (SM+), SIV-negative RM (RM−), SIV-infected RM with a viral load of <10⁶ vRNA copies/ml (RM+), and SIV-infected RM with a viral load of >10⁷ vRNA copies/ml (RM++) were analyzed for the transcription of Plk1 by real-time PCR, and data were normalized to GAPDH and expressed as copy numbers relative to the calibrator sample. Error bars represent SD of values obtained from samples from different animals, and n denotes numbers of animals tested in each group. Statistically significant differences (asterisk; P < 0.001) were detected in RM++ samples compared to both RM+ samples and RM− samples.