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Replication of HIV-1 clones with mutations that impaired the processing and presentation of A*0201 or A24 CTL epitopes in H9 (a) and Jurkat (b) cells. The kinetics of each recombinant virus replication were monitored as the production of p24 antigen by p24 ELISA. Symbols: ○, wild-type; □, A24-3R; ▪, A24-K26S+3R; ▵, A24-3R7L; ▴, A24-1Q3R; •, A*0201-3F8V; ⋄, A*0201-2V; ×, mock.
