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. 2009 Sep 24;150(11):5163–5170. doi: 10.1210/en.2009-0699

Figure 5.

Figure 5

Expression of mutant hMCT8 in JEG3 cells, corresponding to mutations in MCT8 patients. A, Expression of hMCT8 (lane 1), a splice site mutant, which lacks amino acids 267–360 (lane 2), and cotransfection of wt and splice site mutant hMCT8 (lane 3). B, Expression of different hMCT8 mutants. The solid arrow indicates wt hMCT8 monomer; the dashed arrows point to wt hMCT8 dimers and oligomers. C, Uptake of 1 nm [3′-125I]T3 (5 min) in JEG3 cells (co)transfected with a (combination of) hMCT8 mutants.