Fig. 2.

Cyclophilin-D and the mitochondrial phosphate carrier are downregulated in cardiac mitochondria from sedentary but not exercised FH pigs. A: Western blot analysis for the putative mitochondrial permeability transition (MPT) pore components cyclophilin-D (CypD), mitochondrial phosphate carrier (PiC), and adenine nucleotide translocase (ANT) in mitochondrial lysates from NL-Sed, FH-Sed, and FH-Ex hearts (n = 4 in each group). The voltage-dependent anion channel (VDAC), ATP synthase (AtpS), and cytochrome-c oxidase subunit II (COXII) were also blotted for. B: quantification of the mitochondrial protein expression data. Graphs are shown as means ± SE with *P < 0.05 vs. NL-Sed. †P < 0.05 vs. FH-Sed.