Distribution of vigilance states under ad libitum feeding conditions 104 days after Arc injections in NPY-SAP (▵ and white bars) and B-SAP (▴ and black bars) rats. In A–F, shaded regions indicate the dark period. A, C, and E: % time in each vigilance state in 2-h blocks (*P < 0.05, NPY-SAP vs. corresponding B-SAP value). B, D, and F: average amount of time spent in each vigilance state in the dark period vs. light period expressed as minute per 2 h (*P < 0.05, white bar vs. black bar under same condition, #P < 0.05 vs. the same colored bar in the dark period). G, H, and I: total time in the indicated vigilance states during the 22 h of recording (*P < 0.05 vs. adjacent black bar). The sleep-wake changes apparent soon after Arc injections (see Fig. 4) persisted in NPY-SAP rats even after attenuation of lesion-induced hyperphagia.