Table 2.
Functional annotation of gene products elevated in winter states
| Cluster | Enrichment Score | No. of Annotations | Mean Fold Enrichment |
|---|---|---|---|
| Mitochondrion | 14.2 | 3 | 13.8 |
| Mitochondrial matrix | 7.6 | 3 | 11.5 |
| Aerobic respiration | 5.5 | 21 | 52.0 |
| Monosaccharide metabolism | 4.8 | 3 | 12.8 |
| Monosaccharide catabolism | 4.1 | 7 | 23.2 |
| Mitochondrial envelope | 3.5 | 7 | 5.6 |
| Fatty acid catabolism | 3.4 | 9 | 25.7 |
| Membrane-enclosed lumen | 3.0 | 3 | 2.5 |
| Reactive O2 species metabolism | 2.6 | 15 | 29.0 |
| Negative regulation of cell death | 2.5 | 3 | 5.7 |
| Regulation of cell death | 2.1 | 3 | 3.3 |
| Nucleoside binding | 2.1 | 4 | 2.3 |
| Flavoprotein | 1.7 | 4 | 11.3 |
| Membrane-bounded vesicle | 1.6 | 5 | 4.1 |
| Peroxisome | 1.5 | 3 | 10.8 |
| Nucleotide binding | 1.4 | 6 | 2.1 |
Functional annotation clusters were generated using DAVID bioinformatics database with κ similarity = 0.85 (default settings, otherwise). All significantly enriched clusters (≥1.3) are listed. Clusters are described by the top 3 annotation with the widest biological relevance, and the mean pathway fold enrichment for all annotations is reported from each cluster.