Fig. 7.

Sepsis alters activity of the brain stem GABAergic system. Presented are numbers of c-Fos⁺ neurons and c-Fos⁺/GAD₆₇⁺ neurons in the pedunculopontine tegmental nucleus (PPT; top), laterodorsal tegmental nucleus (LDT; middle), and the ventrolateral periaqueductal grey (vlPAG; bottom) of rats after abdominal surgeries. Stereological counts were obtained from tissue in brains of rats killed at 30, 54, and 78 h after SHAM surgeries (open bars) or CLP surgeries (solid bars). Values are means ± SE from n = 4 animals per time point and condition. Statistically significant differences between groups are indicated as *P ≤ 0.05; **P ≤ 0.01.