Fig. 6.
Effects of CN on the kinetics of IK1,tail and IK1,inactivation. A: time dependence of changes in the kinetics of IK1,tail (inset; IK1,tailN) during application of 1 mM CN from a selected experiment. Current recordings were sequentially taken before (1), during (2), and 10 min after (3) application of CN. The data highlight a so-called “crossover” phenomenon (○). At some point during inhibition of tail currents, the total amplitude of IK1,tailN is decreased (2; ▵), while the late current is increased (2; ▴). B: selected examples of changes of inactivation of IK1 before (i) and after (ii) exposure to CN for 10 min. Dotted lines represent the two-exponential fits to the data. B1: no significant change in both fast (τfast) and slow components (τslow). B2: significant increase in the amplitude of τslow. B3: significant decrease in the amplitude of τfast.