Table 1.
Effects of temperature on IK1, IK1 “inactivation”, and CM
| RT |
35°C |
|||||||
|---|---|---|---|---|---|---|---|---|
| [Mg] | 0 min | 5 min | % | <P | 0 min | 5 min | % | <P |
| IK1, pA/pF | ||||||||
| 0 | 35.6 ± 3.9 | 38.8 ± 5.0 | 7.7 | 0.05 | 39.8 ± 4.2 | 52.7 ± 6.2 | 31.5 | 0.01 |
| 5.5 | 30.1 ± 4.5 | 26.8 ± 3.0 | −9.2 | NS | 29.4 ± 1.5 | 35.4 ± 1.8 | 21.3 | 0.05 |
| IK1 “inactivation” (A/IK1) | ||||||||
| 0 | 0.30 ± 0.03 | 0.31 ± 0.03 | −3.7 | NS | 0.29 ± 0.02 | 0.07 ± 0.01 | −76.1 | 0.001 |
| 5.5 | 0.31 ± 0.04 | 0.32 ± 0.03 | −4.1 | NS | 0.39 ± 0.02 | 0.18 ± 0.02 | −54.4 | 0.001 |
| CM, pF | ||||||||
| 0 | 191 ± 25 | 190 ± 24 | −0.15 | NS | 149 ± 8 | 114 ± 6 | −23.5 | 0.001 |
| 5.5 | 171 ± 21 | 171 ± 18 | −0.24 | NS | 204 ± 26 | 159 ± 19 | −21.5 | 0.01 |
[Mg], Mg concentration; RT, room temperature; IK1, inward rectifier potassium current; A, amplitude; CM, membrane capacitance; NS, nonsignificant. %, an average percentage of change for individual cells (n = 5–7). P values were calculated using paired t-test.