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Effect of curcumin on hyperoxia-induced apoptosis in e19 AIFs. Exposure of cultured e19 AIFs to 95% O2 for 24 h resulted in decreased Bcl-2-to-Bax ratio (A), an effect that was blocked by 1 h of pretreatment with 5 μM curcumin. Under normoxic conditions, 24 h of treatment with 20 μM curcumin increased fibroblast apoptosis (decreased Bcl-2-to-Bax ratio), while 5 and 10 μM curcumin had no effect (B). Values are means ± SE.
