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Hyperoxia-induced increase in Smad3 and its nuclear translocation and their blockage by curcumin pretreatment. In cultured e19 AIFs exposed to 95% O2 for 6 h, Smad3 translocated to the nucleus (white arrows), an effect that was at least partially blocked by 1 h of pretreatment with 10 μM curcumin. Original magnification ×20.
