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Functional angiogenesis as assessed by blood flow (% cardiac output) to the left lung 14 days after LPAL. Mice received either PBS (40 μl) or endotoxin-free LMW HA (495–30 kDa; 40 μl of 2.3 mg/ml), delivered 4, 24, 48, and 72 h after LPAL by intratracheal aspiration. Angiogenesis was significantly greater in mice given additional LMW HA fragments compared with PBS-treated mice (*P < 0.05).
