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Rho kinase (ROCK) does not mediate enhanced ET-1-induced vasoconstriction following E-IH. Vasoconstrictor (A) and VSM [Ca2+]i (B) responses to ET-1 in pulmonary arteries from sham and E-IH rats in the presence and absence of the ROCK inhibitor fasudil (10 μmol/l). Data are means ± SE of n = 6–9/group. *P < 0.05 E-IH vs. sham; #P < 0.05 E-IH vs. E-IH + fasudil; ‡P < 0.05 sham + fasudil vs. E-IH + fasudil.
