Fig. 6.

Effect of PGE₂ and iloprost on bleomycin-induced collagen production and development of lung fibrosis. A: lung collagen content 21 days after bleomycin challenge was lower in mice treated with PGE₂ or iloprost. B: representative histology of Masson's trichrome-stained slides. C: calculated fibrosis scores based on histopathological assessment of Masson's trichrome-stained sections revealed a protective effect of PGE₂ in bleomycin-treated lungs. *P < 0.05 vs. vehicle + bleomycin group, †P < 0.05 vs. vehicle + saline group; n ≥ 6 for saline groups, n ≥ 15 for bleomycin groups.