Fig. 7.

Therapeutic effect of PGE₂ and iloprost on lung dysfunction and cellular infiltration following bleomycin. A: mice were challenged with bleomycin and then given vehicle, PGE₂, or iloprost via minipumps 14 days later. Static compliance was measured via FlexiVent 21 days after bleomycin administration. Bleomycin-induced decrease in Cst observed in vehicle-treated animals was not affected by PGE₂ or iloprost. B: PGE₂ and iloprost both inhibited total cell and lymphocyte influx into BALF when administered 14 days after bleomycin challenge. *P < 0.05 vs. vehicle + bleomycin group, †P < 0.05 vs. vehicle + saline group; n ≥ 8 for saline groups, n ≥ 21 for bleomycin groups.