Fig. 1.
The reversible Michaelis-Menten models utilized to extract kinetic parameters for cerebral glucose transport and utilization. The extracted kinetic parameters are shown in dotted boxes. BBB, blood-brain barrier; BCB, blood-cerebrospinal fluid (CSF) barrier; Vint, blood-to-brain glucose transport rate; Voutt, brain-to-blood glucose transport rate; Vmaxt, maximal glucose transport rate through the BBB; KMt, the glucose concentration for half-maximal transport through the BBB; Vmax,BCBt, maximal glucose transport rate through the BCB; KM,BCBt, the glucose concentration for half-maximal transport through the BCB; kd, transport coefficient for diffusion between CSF and brain tissue; Vmaxutil, maximal brain glucose utilization rate; KMutil, brain glucose concentration for half-maximal utilization; CMRglc, cerebral metabolic rate of glucose utilization.