Fig. 5.

Ratio of ¹²⁵I-T₃(T₄) to ¹³¹I-T₃(T₃) is increased in injured skeletal muscle of WT mice but not in D2KO mice. ¹²⁵I-T₃/¹³¹I-T₃ ratio was assessed by paper chromatography in cytosol of regenerating muscles in 8- to 9-wk-old WT and D2KO mice that had received cardiotoxin injection (see materials and methods) into the right anterior tibialis and gastrocnemius 8 days earlier. Contralateral homologous muscles were not injected and served as controls. WT and D2KO mice received ¹²⁵I-T₄ and ¹³¹I-T₃ for 24 and 4 h, respectively, prior to obtaining tissues. Results are means ± SE of 5 animals per group. *P < 0.05.