Table 2. Protein-Protein Interaction network properties of disease genes.

						Largest Connected Component
	Proteins	Inter-actions	Max Degree	Avg Degree	Comps	Proteins	Inter-actions	Avg Degree
Disease Lethal	1943	2778	104	2.9	70	91%	96%	3.0
Disease Viable	1535	1600	92	2.1	151	71%	81%	2.4
Lethal	3638	7083	138	3.9	86	94%	98%	4.1
Viable	1436	1654	71	2.3	86	84%	91%	2.5
Disease Un-known	5116	8918	92	3.5	224	89%	96%	3.8

Data for PPI networks for disease lethal (DL), disease viable (DV), lethal (L), viable (V) and disease unknown (DU) genes. “Proteins” represent the sum of proteins in a given group (DL, DV, L, V or DU) and their interacting partners (from any group). Statistical analysis was performed for all interactions (e.g. proteins of the same classification and proteins of different classifications). The total number of PPIs are indicated under “Interactions” and the number of PPIs for the most highly connected protein is indicated under “MaxDegree”. “Average Degree” corresponds to the mean number of PPIs for all interacting proteins. “Comps” designates the number of independent groups (components) of interactions, the largest of which comprises the “Largest Connected Component”. The percentages of proteins and interactions, and the average degree found within the largest connected component are given.