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. 2011 Nov 11;6(11):e27265. doi: 10.1371/journal.pone.0027265

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Konar et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) i-Extract treatment resulted in increased viability of C6 cells. (B) Composition of i-Extract (the content of Withaferin A and Withanone is shown. (C) IMR32 cells treated with scopolamine and i-Extract, Withaferin A and Withanone (i-Factor) supplemented medium are shown. (D) TUNEL assay of the control and treated cells (as indicated) showed apoptosis in scopolamine treated cells. Pre-treatment of cells and recovery in i-Extract supplemented medium showed downregulation of scopolamine induced apoptosis.