Table 3. AUC, IDI, NRI, and RCS for the combined assessment of eGFR and traditional risk factors in predicting mortality, incident stroke, and CHD.
| AUC | IDI | NRI | RCS | |
| All-cause mortality | ||||
| Model 1* | 0.876 (0.854–0.898), P<0.001 | / | - | - |
| Model 2† | 0.883 (0.862–0.905), P<0.001 | 1.51% | - | - |
| P value vs. model 1 | 0.525 | 0.016 | - | - |
| CVD mortality | ||||
| Model 1* | 0.873 (0.846–0.900), P<0.001 | / | - | - |
| Model 2† | 0.885 (0.858–0.911), P<0.001 | 1.99% | - | - |
| P value vs. model 1 | 0.374 | 0.017 | - | - |
| Incident stroke | ||||
| Model 1* | 0.707 (0.662–0.752), P<0.001 | / | / | x 2 = 13.463, P = 0.019 |
| Model 2† | 0.726 (0.683–0.770), P<0.001 | 0.91% | 5.9% | x 2 = 10.065, P = 0.073 |
| P value vs. model 1 | 0.399 | 0.024 | 0.012 | - |
| Incident CHD | ||||
| Model 1* | 0.887 (0.850–0.925), P<0.001 | / | / | x 2 = 2.958, P = 0.398 |
| Model 2† | 0.891 (0.856–0.926), P<0.001 | 0.30% | 1.8% | x 2 = 2.803, P = 0.423 |
| P value vs. model 1 | 0.829 | 0.438 | 0.823 | - |
*Variables included age, sex, Mongolian ethnicity, systolic blood pressure, diastolic blood pressure, pulse rate, body mass index, antihypertensive drug use, current smoking, current drinking, diabetes mellitus, serum uric acid, total cholesterol, HDL-C, and lipid-lowering drug use.
†
Model 1 + eGFR.
eGFR, estimated glomerular filtration rate; AUC, area under the curve; IDI, integrated discrimination improvement; NRI, net reclassification improvement; RCS, reclassification calibration statistic; CVD, cardiovascular disease; CHD, coronary heart disease.
NRI and RCS computed for incident stroke and CHD only, because the lack of established thresholds of risk for all-cause and CVD mortality.