Table 1. Comparison of the dynamin 2 disease-causing mutations tested.

Disease	CMT		CNM
Mutations	G358R	K562E	R465W	R522H	S619L	P627H
Affected domain	Middle	PH	Middle	PH	PH	PH
Localization to MT's1	+	+	-	-	-	-
MT dynamics2			MT stability not affected		MT stability not affected
CME and clathrin-positive structures1	normal and clustered	strongly decreased and clustered	decreased and enlarged	decreased and enlarged	decreased and enlarged	decreased and enlarged
CME in patient cells2			normal		normal
Golgi maintenance1,2	normal	normal	normal	normal	normal	normal
Centrosome cohesion1,2	normal	normal	normal	normal	normal	normal

¹ectopic expression, ²in patient fibroblasts.