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. 2011 Jul 27;106(5):2189–2200. doi: 10.1152/jn.00164.2011

Fig. 2.

Fig. 2.

Reduction in hyperpolarization-activated current Ih-dependent voltage changes in L5 pyramidal neurons from lesioned animals. A: specimen records showing that membrane hyperpolarization in sham-operated animals is associated with a depolarizing “sag” in membrane voltage caused by Ih activation. Rebound depolarizations (Dep) are also seen. B: superimposed specimen records showing that sag responses are reduced in a pyramidal neuron near the freeze lesion. Rebound depolarizations upon current offset are also reduced. C: summary graphs showing a significant reduction in the amplitude in the voltage sag (left) and rebound depolarization (right) in pyramidal neurons from freeze-lesioned animals.