Fig. 2.
Reduction in hyperpolarization-activated current Ih-dependent voltage changes in L5 pyramidal neurons from lesioned animals. A: specimen records showing that membrane hyperpolarization in sham-operated animals is associated with a depolarizing “sag” in membrane voltage caused by Ih activation. Rebound depolarizations (Dep) are also seen. B: superimposed specimen records showing that sag responses are reduced in a pyramidal neuron near the freeze lesion. Rebound depolarizations upon current offset are also reduced. C: summary graphs showing a significant reduction in the amplitude in the voltage sag (left) and rebound depolarization (right) in pyramidal neurons from freeze-lesioned animals.