Fig. 4.
Voltage-clamp recordings of Ih in neurons from sham-operated and lesioned animals. A, top: ZD7288-sensitive somatic Ih currents obtained by subtracting obtained before and after bath application of ZD7288 in a L5 pyramidal neurons from a sham-operated animal. Slowly activating Ih currents are observed. Bottom: recordings from a neuron near the freeze lesion revealed a significant decrease in Ih amplitude following membrane hyperpolarization. B: summary diagram showing current-voltage plots for a group of neurons in sham-operated and lesioned animals. *P < 0.05.