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. 2011 Jul 27;106(5):2189–2200. doi: 10.1152/jn.00164.2011

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Copyright © 2011 the American Physiological Society

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Fig. 9. — Effects of the anticonvulsant lamotrigine on evoked network activity. A: typical network response evoked in a control animal before lamotrigine. B: response to the same stimulation 20 min after application of lamotrigine. C: responses from individual diodes before (blue) and after (red) lamotrigine. D: lamotrigine (LTG) reduced the amplitude of diode responses in control in control animals. This effect was significantly attenuated by coapplication of ZD7288 (ZD). E: lamotrigine reduced the number of diodes activated (indicating spread of activity) in control animals. This effect was also significantly attenuated by coapplication of ZD7288.