Fig. 6.
Adrenergic modulation of Ih-mediated effects in corticospinal neurons. Voltage traces (−100 pA, 0.5 s step; −70 holding, 34°C) of a (A) corticospinal neuron, (B) corticostriatal neuron, and (C) corticospinal neuron recorded with intracellular (IC) ZD7288 before and after combined treatment with the α1-adrenergic agonist cirazoline (1 μM) and the α2-adrenergic agonist guanfacine (40 μM). Plots to the right of the traces show the mean (±SE) effect of adrenergic agonists on voltage sag and resonance corticospinal neurons (n = 7), corticostriatal neurons (n = 7), corticospinal neurons recorded with intracellular ZD7288 (n = 6; *P < 0.05, pair-wise t-test).