Fig. 1.

Homology analysis of prestin. A: region, domain, and motif designation of the human prestin amino acid sequence: green, transmembrane region; blue, sulfate transporter (SulP) domain; red, sulfate transporter and anti-sigma factor antagonist (STAS) domain; and yellow, SulP motif. B: phylogeny of SulP family member proteins. The number at each node indicates the bootstrap number out of 100 repetitions. C: multiple sequence alignment of cysteinyl residues. Residue properties are indicated as follows: gray, small hydrophobic; green, medium-size hydrophobic; cyan, partial positive charge; blue, positive charge; orange, partial negative charge; red, negative charge; pink, proline; light purple, histidine; and yellow, special property.