Fig. 6.
Effect of selective increases in GABAergic and glycinergic inhibition on the deactivation of synaptically activated plateau/PIC and SSF. A: schematic of the α-MN-RC network construct. Iex is a tonic dendritic excitation of the α-MN. B: excitatory input (duration marked by open horizontal bars) activated dendritic plateau (asterisk) and induced soma firing. Plateau activation and SSF persisted after removal of the excitatory input under default levels of GABAA and glycinergic inhibitory conductances. C: 2-fold increase in GABAA conductance (horizontal black line) completely deactivated the plateau and inhibited SSF. D: 2-fold increase in glycinergic conductance did not completely deactivate the plateau, and SSF ensued. Vden, dendritic voltage.