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. 2011 Aug 24;106(5):2709–2719. doi: 10.1152/jn.00178.2011

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Fig. 7. — Postinhibitory rebound (PIR) and low voltage-activated (LVA) Ca²⁺ spike in a neuron at E18. A: membrane depolarizations and AP spikes (asterisk) induced by PIRs after membrane hyperpolarizations, which were evoked by negative current injection steps (0–30 pA in 5 pA step, 2-s duration). ACSF, artificial cerebrospinal fluid. B: termination of hyperpolarizations of A with expanded time scale. C: membrane depolarizations induced by PIRs in the presence of TTX (filled arrowhead). D: membrane depolarizations in the presence of NiCl₂ and TTX. Transient membrane depolarizations were eliminated by NiCl₂ (open arrowhead). E: Ni²⁺-sensitive spikes (filled arrowhead) computed by subtraction of traces in D from those in C, indicating LVA Ca²⁺ spikes. F: expanded voltage and time scale of traces in E. Intensities of hyperpolarizing currents are indicated on the right of each trace of the Ca²⁺ spikes. G: relationship between Ca²⁺-spike amplitudes and different age groups. H: relationships of hyperpolarized V_m with Ca²⁺-spike amplitude in prenatal (circles) and postnatal (triangles) neurons. The spike amplitudes were normalized to the maximum amplitude.