Table 1.
Electrophysiological properties of prenatal and early postnatal neurons in rNST
| E14/16 | n | E18/20 | n | P0-2 | n | P6-8 | n | P14-20 | n | |
|---|---|---|---|---|---|---|---|---|---|---|
| Vrest (mV) | −36 ± 2 | 19 | −49 ± 2 | 18 | −52 ± 2 | 23 | −49 ± 2 | 15 | −56 ± 1 | 36 |
| Rinput (GΩ) | 2.0 ± 0.4 | 19 | 1.9 ± 0.2 | 18 | 1.3 ± 0.2 | 23 | 1.0 ± 0.1 | 15 | 0.7 ± 0.1 | 36 |
| Membrane time constant (ms) | 92 ± 14 | 19 | 75 ± 6 | 22 | 70 ± 9 | 23 | 55 ± 5 | 19 | 41 ± 3 | 36 |
| Cm (pF) | 31 ± 1 | 19 | 37 ± 2 | 18 | 52 ± 3 | 23 | 52 ± 4 | 15 | 56 ± 3 | 36 |
| AP threshold (mV) | −30 ± 2 | 14 | −34 ± 1 | 20 | −36 ± 1 | 25 | −38 ± 2 | 18 | −39 ± 1 | 39 |
| AP height (mV) | 18 ± 2 | 14 | 34 ± 3 | 20 | 43 ± 3 | 25 | 50 ± 3 | 18 | 61 ± 2 | 39 |
| AP peak potential (mV) | −12 ± 2 | 14 | −0.4 ± 3 | 20 | 7 ± 2 | 25 | 12 ± 2 | 18 | 22 ± 1 | 39 |
| AP rising velocity (mV/ms) | 8 ± 1 | 24 | 19 ± 2 | 26 | 34 ± 4 | 29 | 44 ± 5 | 19 | 82 ± 4 | 40 |
| AP falling velocity (mV/ms) | 5 ± 0.3 | 24 | 8 ± 1 | 26 | 16 ± 4 | 29 | 22 ± 2 | 19 | 45 ± 2 | 40 |
| AP half-width (ms) | 12 ± 1 | 14 | 6 ± 1 | 20 | 4 ± 0.3 | 25 | 3 ± 0.3 | 18 | 1.7 ± 0.1 | 39 |
| AHP amplitude (mV) | 5 ± 1 | 14 | 7 ± 1 | 20 | 12 ± 1 | 25 | 15 ± 1 | 18 | 15 ± 1 | 39 |
| AHP peak time (ms) | 20 ± 3 | 14 | 14 ± 2 | 20 | 16 ± 1 | 25 | 16 ± 2 | 18 | 6 ± 1 | 39 |
| AP discharge rate (/s) | 1 ± 3 | 35 | 3 ± 1 | 27 | 8 ± 1 | 30 | 11 ± 2 | 20 | 17 ± 1 | 39 |
| IKA amplitude (pA) | 77 ± 12 | 29 | 143 ± 18 | 23 | 182 ± 30 | 28 | 242 ± 32 | 14 | 247 ± 33 | 25 |
| IKA decay time constant (ms) | 23 ± 2 | 14 | 29 ± 4 | 17 | 44 ± 8 | 20 | 43 ± 12 | 11 | 99 ± 12 | 19 |
| Ih amplitude (pA) | 12 ± 3 | 14 | 17 ± 2 | 18 | 32 ± 5 | 22 | 36 ± 7 | 13 | 29 ± 4 | 27 |
Values are means ± SE. rNST, rostral nucleus of the solitary tract; E, embryonic day; P, postnatal day; Vrest, resting membrane potential; Rinput, input resistance; Cm, membrane capacitance; AP, action potential; AHP, after-hyperpolarization; IKA, transient outward potassium current; Ih, inward current.