Table 3.
Univariate analysis of 3-year survival
| LRC (%) | p | DMFS (%) | p | DFS (%) | p | DSS (%) | p | OS (%) | p | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Stage | I-II III-IV |
81.8 66.4 |
0.245 | 84.6 77.5 |
0.548 | 69.2 55.1 |
0.282 | 76.9 60.4 |
0.208 | 76.9 54.2 |
0.033 |
| T stage | T1-2 T3-4 |
77.5 61.6 |
0.145 | 81.9 75.6 |
0.458 | 66.3 49.6 |
0.139 | 71.3 55.9 |
0.144 | 66.7 50.4 |
0.021 |
| N stage | N0-1 N2-3 |
74.1 62.2 |
0.196 | 87.5 66.8 |
0.023 | 66.7 45.8 |
0.024 | 75.8 46.6 |
0.007 | 72.3 40.0 |
0.002 |
| Depth (millimeters) | ≤10 > 10 |
61.2 74.8 |
0.367 | 90.0 71.7 |
0.118 | 55.1 58.8 |
0.938 | 67.9 60.3 |
0.694 | 62.4 55.1 |
0.417 |
| Differentiation | Well Moderate Poor |
72.0 67.1 75.0 |
0.818 | 86.6 82.5 37.5 |
0.003 | 66.0 56.6 37.5 |
0.264 | 70.2 64.1 37.5 |
0.203 | 66.7 56.8 37.5 |
0.580 |
| Nodal ECS | No Yes |
78.1 53.8 |
0.049 | 87.9 63.7 |
0.019 | 70.7 38.3 |
0.005 | 79.5 39.4 |
0.001 | 75.6 34.3 |
0.001 |
| Skin invasion | No Yes |
71.6 41.7 |
0.153 | 81.3 51.4 |
0.076 | 60.5 28.6 |
0.071 | 67.0 28.6 |
0.033 | 60.8 28.6 |
0.204 |
| Bone invasion | No Yes |
71.6 62.7 |
0.407 | 74.5 90.7 |
0.226 | 57.7 56.9 |
0.871 | 64.2 60.2 |
0.940 | 58.9 54.8 |
0.251 |
| Perineural invasion | No Yes |
68.1 71.9 |
0.717 | 81.3 69.2 |
0.295 | 58.6 51.9 |
0.349 | 67.8 50.0 |
0.170 | 62.0 45.8 |
0.318 |
| Blood vessel invasion | No Yes |
67.5 80.0 |
0.729 | 78.0 75.0 |
0.999 | 56.0 60.0 |
0.891 | 62.4 60.0 |
0.909 | 56.6 60.0 |
0.741 |
| Lymphatic vessel invasion | No Yes |
67.6 75.8 |
0.845 | 81.9 55.6 |
0.014 | 58.1 46.3 |
0.218 | 65.1 45.8 |
0.106 | 59.6 41.7 |
0.117 |
| Margin status (millimeters) | ≥ 5 < 5 |
67.1 80.8 |
0.406 | 77.3 84.6 |
0.737 | 55.4 68.4 |
0.517 | 59.2 83.3 |
0.152 | 54.1 65.9 |
0.157 |
| Concurrent chemotherapy | No Yes |
70.8 67.8 |
0.613 | 89.3 66.0 |
0.014 | 65.2 48.9 |
0.071 | 72.6 52.4 |
0.506 | 70.6 44.3 |
0.022 |
| GP96 overexpression | No Yes |
90.2 58.7 |
0.008 | 95.8 69.5 |
0.018 | 86.5 44.7 |
0.001 | 95.7 49.0 |
0.001 | 87.5 44.9 |
0.003 |
Abbreviation: LRC = locoregional control; DMFS = distant metastasis-free survival; DFS = disease-free survival; DSS = disease-specific survival; OS = overall-survival; ECS = extra-capsular spreading.