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Smooth muscle cell actin in the media of aorta was decreased in hypertensive animals, both spices substances reversed this decrease. Immunohistochemical detection of smooth muscle actin (right) and evaluation in graphic form (left). CSA - cross sectional area, Con - control, L - L-NAME induced hypertension, P - piperine, C - curcumin. ++ p < 0.01 versus L,+++ p < 0.001 versus L, ** p < 0.01 versus Con, *** p < 0.001 versus Con.
