Table 1.
Characteristics of various phenotypes of androgen excess and/or anovulation
| Group | Group1 (PCOS) N = 85 |
Group 2 menstrual dysfunction per se N = 15 |
Group 3 (CH+BH) N = 43 |
Group 4 (IH) N = 130 |
Group 5 (Normal) N = 718 |
|---|---|---|---|---|---|
| Age | a 27.0 (21.0-35.0) | 29.0 (20.0-34.5) | 30.0 (23.0-35.0) | 33.0 (26.0-38.0) | 29.0 (21.0-36.0) |
| Age at menarche | 13.0 (12.0-13.0) | 13.0 (12.5-13.5) | 13.0 (13.0-14.0) | 13.0 (12.0-14.0) | 13.0 (13.0-14.0) |
| Women with history of primary Infertility % | b 8.2 | 5.7 | 3.7 | 2.2 | 1.7 |
| Women with family history of hirsutism % | b 58.8 | 39.6 | b 40.7 | b 49.6 | 24.9 |
| Women with family history of anovulation % | b 32.9 | 30.2 | 29.6 | 24.1 | 17.0 |
| Women with family history of infertility % | b 9.4 | 3.8 | 4.8 | 2.9 | 2.9 |
| Women with history of abortion % | 14.1 | 18.9 | 11.1 | 17.5 | 17.3 |
| No. Pregnancy | 1.0 (0-2.0) | 1 (0-2.0) | 0 (0-2) | 2.0 (1.0-3.0) | 1 (0-2) |
| BMI (kg/m2) | 26.2 (22.3-30.5) | 26.2 (22.4-29.2) | 24.1 (22.1-27.9) | b 26.7 (23.7-29.7) | 24.5 (21.2-28.7) |
| Waist circumference (cm) | 85.0 (78.0-98.5) | 83.0 (75.5-92.5) | 81.0 (74.0-92.0) | 88.0 (79.5-98.5) | 82.0 (73.0-91.0) |
| Hip circumference (cm) | 104.0 (97.0-110.5) | 101.0 (96-109.5) | 99.0 (94.0-110.0) | b 105.0 (100.0-110.5) | 101.0 (95.0-107.8) |
| Wrist circumference (cm) | 15.5 (15.0-16.5) | 15.5 (15.0-16.2) | 15.2 (14.5-16.0) | 15.8 (15.2-16.5) | 15.5 (15.0-16.2) |
| Systolic Blood Pressure (mmHg) | 102.5 (98.0-111.3) | 100.0 (90.3-112.3) | 106.0 (98.0-112.3) | 106.5 (98.3-116.8) | 106.0 (98.0-114.0) |
| Diastolic Blood Pressure (mmHg) | 70.0 (65.0-75.0) | 70.0 (68.8-81.3) | 72.0 (68.8-81.3) | 71.5 (65.0-77.0) | 71.0 (64.0-76.0) |
| FBS | 87.0 (81.5-91.5) | 101.0 (96.0-109.5) | 86.0 (81.0-89.0) | 87.0 (81.3-95.0) | 86.0 (81.0-92.0) |
| TT | a 0.5 (0.3-0.7) | 0.5 (0.4-0.8) | c 0.4 (0.3-0.8) | d 0.3 (0.2-0.4) | 0.4 (0.2-0.6) |
| SHBG | b, e 37.0 (27.0-43.0) | b, f 58.0 (46.0-106.0) | 36.0 (25.0-41.0) | b, d 38.0 (28.0-45.0) | 45.5 (39.0-54.8) |
| FAI | a, b, e 3.4 (2.2-3.8) | f 2.1 (2.0-4.4) | c 5.1 (3.2-7.7) | 2.4 (1.9-3.6) | 2.4 (1.5-4.2) |
| DHEAS | 119.0 (77.0-162.3) | 122.0 (85.7-139.2) | c 180.0 (123.0-221.8) | 96.0 (64.0-130.0) | 124.0 (75.5-145.3) |
| A4 | b 1.4 (0.6-2.3) | 1.1 (0.3-1.4) | 1.5 (0.9-2.7) | 1.1 (0.5-1.6) | 0.8 (0.5-1.7) |
PCOS, polycystic ovary syndrome using NIH definition; CH, clinical hyperandrogenism; BH, biochemical hyperandrogenemia; IH, idiopathic hirsutism; Normal group, eumenorrheic without hirsutism. BMI, body mass index; DHEAS, Dehydroepiandrosterone sulfate; Total T, Total testosterone; A4, Androstendion; SHBG, Sex Hormone Binding Globulin; FAI, Free androgen index
Values are given as median (Inter quartile range), a = Group 1 vs. Group 4; b = vs. normal group, p < 0.001, c = Group 3 vs. Group 4, p < 0.001; d = Group 2 vs. Group 4, p < 0.001; e = Group1 vs. Group 2, p < 0.001; f = Group 2 vs. Group 3, p < 0.001
The hormonal profile of women on hormonal therapy (n = 31) were excluded from statistical analysis.