Table 7.

Linear Regression Results^a for Continuous Semen Profile Measurements with PFOS Concentrations in Semen and Plasma

				PFOS (ng/mL)			PFOA (ng/mL)
Parameter			N	Coefficient	95% Confidence Interval	p Value	Coefficient	95% Confidence Interval	p Value
Volume (mL)	Plasma
		Unadjusted	248	−0.0034	−0.0123–0.0055	0.454	0.0189	−0.0122–0.0500	0.231
		Adjustedb	231	− 0.0023	0.0121–0.0061	0.517	0.0148	−0.0179–0.0475	0.373
	Semen
		Unadjusted	169	0.0569	−0.2130–0.3269	0.678	—a
		Adjusted	157	− 0.0017	−0.2875–0.2841	0.991	—a
pH	Plasma
		Unadjusted	247	0.0009	−0.0008–0.0026	0.280	−0.0020	−0.0080–0.0041	0.523
		Adjusted	231	0.0007	−0.0010–0.0025	0.420	−0.0010	−0.0073–0.0054	0.761
	Semen
		Unadjusted	168	−0.0117	−0.0397–0.0630	0.654	—a
		Adjusted	157	0.0267	0.0297–0.0830	0.351	—a
Sperm concentration (× 106/mL)	Plasma
		Unadjusted	247	0.1222	−0.2463–0.4907	0.514	0.4904	−0.7952–1.7760	0.453
		Adjusted	230	0.1568	−0.2256–0.5392	0.420	0.1373	−1.2396–1.5142	0.844
	Semen
		Unadjusted	168	3.9064	−6.7423–14.5551	0.470	—a
		Adjusted	156	2.8910	−8.7529–14.5349	0.625	—a
White blood cell concentration (×105/mL)	Plasma
		Unadjusted	247	−0.0022	−0.0075–0.0032	0.426	−0.0003	−0.0199–0.0184	0.977
		Adjusted	230	−0.0020	−0.0072–0.0033	0.456	−0.0019	−0.0207–0.0170	0.847
	Semen
		Unadjusted	169	0.1514	−0.0092–0.3120	0.064	—a
		Adjusted	157	0.1500	−0.0095–0.3093	0.065	—a
Percent motile	Plasma
		Unadjusted	246	0.0334	−0.0747–0.1416	0.543	0.2354	−0.1436–0.6143	0.222
		Adjusted	229	0.0449	−0.0664–0.1561	0.428	0.2687	−0.1315–0.6689	0.187
	Semen
		Unadjusted	168	0.7748	−2.5987–4.1483	0.651	—a
		Adjusted	156	1.1456	−2.5323–4.8235	0.539	—a
Initial total motile (× 106/mL)	Plasma
		Unadjusted	246	0.1131	−0.2382–0.4643	0.527	0.9091	−0.3215–2.1396	0.147
		Adjusted	229	0.1613	−0.1870–0.5095	0.362	0.5438	−0.7094–1.7969	0.393
	Semen
		Unadjusted	168	6.8810	−3.6590–17.4210	0.199	—a
		Adjusted	156	4.7108	−6.1641–15.5856	0.393	—a
Percent swim-up overnight motility	Plasma
		Unadjusted	240	0.0092	−0.0723–0.0908	0.824	0.1223	−0.1634–0.4080	0.400
		Adjusted	223	0.0162	−0.0689–0.1013	0.708	0.1582	−0.1476–0.4640	0.309
	Semen
		Unadjusted	162	0.5846	−2.0128–3.1821	0.657	—a
		Adjusted	150	1.2332	−1.6248–4.0911	0.395	—a
Swim-up concentration (× 106/mL)	Plasma
		Unadjusted	243	−0.0011	−0.0085–0.0064	0.776	0.0158	−0.0103–0.0419	0.235
		Adjusted	226	−0.0011	−0.0088–0.0067	0.788	0.0123	−0.0157–0.0404	0.386
	Semen
		Unadjusted	165	0.0043	−0.2674–0.2588	0.974	—a
		Adjusted	153	0.0340	−0.2565–0.3244	0.818	—a
Percent swim-up motility	Plasma
		Unadjusted	241	0.0001	−0.0559–0.0560	0.999	0.0556	−0.1401–0.2516	0.576
		Adjusted	224	0.0017	−0.0567–0.0601	0.954	0.0300	−0.1797–0.2396	0.778
	Semen
		Unadjusted	162	0.3798	−0.5482–1.3078	0.420	—a
		Adjusted	150	0.3504	−0.6086–1.3093	0.471	—a
Swim-up total motile (× 106/mL)	Plasma
		Unadjusted	238	−0.0009	−0.0083–0.0065	0.815	0.0115	−0.0144–0.0374	0.382
		Adjusted	221	−0.0007	−0.0084–0.0070	0.850	0.0085	−0.0193–0.0362	0.548
	Semen
		Unadjusted	160	−0.0136	−0.2754–0.2481	0.918	—a
		Adjusted	148	0.0256	−0.2621–0.3133	0.861	—a

Note: PFOA = perfluorooctanoic acid, PFOS = perfluorooctane sulfonate

^aThere was insufficient PFOA measurements in semen above the method detection limit to support linear modeling.

^bLinear models included adjustment for age, period of abstinence, and tobacco use.