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Pedigrees of the Dutch families with autosomal recessive hearing impairment and segregation of the TMPRSS3 mutations. Family E is previously described by Cremers et al. (1987). All unaffected sibs were either carrier of one mutant allele or of two wild-type alleles. Square, male; circle, female; open symbol, clinically unaffected; solid symbol, clinically affected; slash, deceased individuals. NT not tested.
