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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Microvasc Res. 2011 May 20;83(1):31–44. doi: 10.1016/j.mvr.2011.05.004

Figure 7. S1P1 signaling leading to FAK activation and enhancement of endothelial barrier function.

Figure 7

Upon ligation of S1P1 by S1P, the Gαi (or) Gβγ subunit mediates an increase in intracellular Ca2+ leading to FAK activation. FAK regulates Rac1 to modulate adherens junction assembly which is required for strengthening of the endothelial barrier.