Table 1.

Dosages of steroidogenesis inhibitors used in patients with Cushing’s disease

Drug	Initial dosage	Maximal dosage	Total daily dose
Ketoconazole	200 mg bid	400 mg tid	1200 mg
Metyrapone	250 mg qid	1500 mg qid	6000 mg
Mitotane	500 mg tid	3000 mg tid	9000 mg
Etomidate	Bolus of 0.03 mg/kg iv followed by infusion 0.1 mg/kg·h	0.3 mg/kg·h

These recommendations are from the international consensus panel. Local prescribing information should be consulted because of regional differences in regulatory approvals. bid, Twice daily; qid, four times daily; tid, three times daily.