TABLE 4.
P. falciparum CQ treatment failure in vivo for selected countries in Asia, 1996 to 2002
| Region | Country | No. of data points identified | Period | Age range (yr) | Outcome classification | Period of follow-up (days) | Median %CQ-PF (range)a | Median %CQ-TTF (range)a | Source or reference |
|---|---|---|---|---|---|---|---|---|---|
| East Asia | China | 1 | 1995-1996 | 6-60 | WHO 1973 | 28 | 91 | 102 | |
| Laos | 1 | 2001 | >1 | WHO 1973 | 28 | 46 | 164 | ||
| Myanmar | 2 | 1995 | All | WHO 1973 | 28 | 82 (77-86) | 190 | ||
| Indonesia | 5 | 1995-1999 | ≥5 | WHO 1973 | 28 | 38 (25-82) | 15, 77, 78, 79, 123, 141 | ||
| Malaysia | 1 | 1996 | 5-51 | WHO 1973 | 28 | 64 | 117 | ||
| Pacific | Philippines | 1 | 1995 | 5-67 | WHO 1973 | 28 | 38 | 14 | |
| Solomon Islands | 1 | 1994-1996 | 5-14 | WHO 1973 | 7 | 23 | 100 | ||
| Indian subcontinent | Bangladesh | 1 | 1996-1997 | 12-60 | WHO 1973 | 28 | 77 | 66 | 170 |
| India | 1 | 2000 | 16-72 | WHO 1973 | 7 | 82 | 81 | ||
| Pakistan | 1 | 1994 | All | WHO 1973 | 28 | 46 | 179 | ||
| Middle East | Afghanistan | 3 | 1999 | >1 | WHO 1973 | 28 | 69 (60-83) | 169 | |
| Saudi Arabia | 1 | 1997-1998 | 1-75 | WHO 1973 | 14 | 12 | 80 | ||
| Saudi Arabia | 1 | 1997-1998 | 1-12 | WHO 1973 | 28 | 18 | 2 |
a
CQ-PF, CQ parasitologic failure (either R1-R3 or cumulative parasite failure); CQ-TF, CQ clinical failure (either ETF + LTF or cumulative clinical failure).