TABLE 3.
CP5-specific antibodies given intraperitoneally protect against endocarditis in rats challenged with serotype 5 S. aureusa
| Challenge strain and dose of S. aureus and IgG type | Log CFU/ml of blood at 24 h | No. of rats infected/total | Vegetation wt (g) | Log CFU/g of vegetation | Log CFU/g of kidney |
|---|---|---|---|---|---|
| Reynolds (4 × 107 CFU) | |||||
| Normal | 4.31 | 4/4 | 0.012 | 11.0 | 7.33 |
| CP-specific | 0.70 | 0/5 | 0 | 3.4 | 1.05 |
| Lowenstein (6 × 107 CFU) | |||||
| Normal | 1.30 | 8/11 | 0.011 | 11.0 | 7.84 |
| CP-specific | 0.70 | 4/13 | 0.003 | 3.4 | 4.85 |
| VP (7 × 107 CFU) | |||||
| Normal | 3.93 | 7/9 | 0.009 | 10.2 | 7.20 |
| CP-specific | 0.70 | 1/9 | 0 | 3.4 | 2.06 |
a
Data are adapted from Lee et al. (66) with permission.