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. Author manuscript; available in PMC: 2011 Nov 13.
Published in final edited form as: Arch Gen Psychiatry. 2011 Jan 3;68(5):505–515. doi: 10.1001/archgenpsychiatry.2010.193

Figure 2.

Figure 2

Significant between treatment group differences in change in regional brain activation from before to after treatment during the crave resist vs neutral cue condition. Bupropion-treated participants exhibited significantly greater treatment-induced reductions in activation in the left ventral striatum (A), bilateral anterior cingulate cortex (A and B), and right medial orbitofrontal cortex (B) compared with placebo-treated participants (z threshold >2.3; cluster threshold, P < .05). Z-axis values correspond to MNI152 standard space coordinates.