TABLE 4.
Tests for antibody detection in human CE and AEa
| Echinococcosis form and test | Antigenb | Sensitivity (%) | Relative specificityc (%) | Cross-reactions |
|---|---|---|---|---|
| Cystic | ||||
| IgG ELISA | Crude EgCF | 80->99 | 61.7 | Cestodes (89%), trematodes (30%), nematodes (39%) |
| Antigen B (native or synthetic peptide) | 63-92 | 85-93 | AE | |
| IgG4 ELISA | Crude EgCF | 61-67 | >99 | AE only (see AE) |
| EITBd | Crude EgCF | 71 | >98e | T. solium cysticercosis only |
| Antigen B fraction | 92 | 100 | None | |
| Antigen B subunits | 34-36 | >90 | ||
| Alveolar | ||||
| IgG ELISA | Crude EgCF | 97.1 | 61.7 | See above |
| Em2PLUS | 97.1 | 98.9 | CE (25%) | |
| Em2/Em2G11 | 89.3 | 100 | CE (5.6%) | |
| Em II/3-10 | 86.4 | 98.4 | CE (6.5%) | |
| IgG4 ELISA | Crude EgCF | 48-67 | >99 | CE (see CE) |
| EITB | Em18 | 97 | 100 | None |
| Glycoproteins | 70-90 | >95 |
a
Data from references 84, 87, 90, 168, 186, and other sources.
b
EgCF, E. granulosus cyst fluid; Em, E. multilocularis.
c
Tested with panels of 80 to 184 sera from patients with different parasitic infections (excluding Echinococcus-infected patients).
d
EITB, enzyme-linked immunoelectrotransfer blot.
e
Including additional sera from patients with other diseases.